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. 2022 Feb 16;13(2):157. doi: 10.1038/s41419-021-04210-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A LncRNA ROR expression in PTC tissue and adjacent tissue samples of patients with PTC as detected by RT-qPCR, normalized to GAPDH (n = 85). *p < 0.05 vs. adjacent tissues. B LncRNA ROR expression in PTC cell lines TPC-1, BCPAP, IHH4, as well as normal thyroid Nthy-ori 3-1 cell line as detected by RT-qPCR, normalized to GAPDH. *p < 0.05 vs. Nthy-ori 3-1. C LncRNA ROR overexpression and silencing efficiency in TPC-1 cells verified by RT-qPCR. D TPC-1 cell viability after alteration of lncRNA ROR as detected by MTT. E Size and number of colonies in TPC-1 cells after alteration of lncRNA ROR, as detected by colony formation assay. F TPC-1 cell migration and invasion after alteration of lncRNA ROR as detected by Transwell assay (×200). G TPC-1 cell apoptosis after alteration of lncRNA ROR as detected by flow cytometry. *p < 0.05 vs. Nthy-ori 3-1 cells or oe-NC, ^#p < 0.05 vs. sh-NC. Cell experiments were repeated three times independently.