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. 2022 Feb 3;12:766490. doi: 10.3389/fonc.2022.766490

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Copyright © 2022 Lu, Qiu, Xie, Li, Duan, Li, Ma, Cheng and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association analysis of 18F-FDG uptake in multiple regions. (A) Time–activity curves of 18F-FDG uptake at different sites. Analyses of (B) Pearson’s correlation coefficient and (C) cosine similarity index for time–activity curves between every two regions. The association between Regions A and B experiences highest Pearson’s correlation coefficient and cosine similarity index among the associations between every two regions, which confirms our speculation that Region B is the possible primary tumor site for Region A.