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. 2022 Feb 16;12:2610. doi: 10.1038/s41598-022-06677-8

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transport of coumarin-6-labeled Ang-MIC acrossed the BBB model in vitro. (A) The signal of micelles transported across the BBB was plotted with time. (B) Transport rate of micelles acrossed the BBB. The uptake of micelle by Skbr-3 cells in the receptor cells (C) imaged by a fluorescence scope and (D) quantitatively determined by flow cytometry.