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. 2022 Feb 16;12:2610. doi: 10.1038/s41598-022-06677-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Brain tumor accumulation of Ang-MIC. (A) In vivo imaging of tumor-bearing mice administrated with DiR-labeled Ang-MIC. (B) Ex vivo imaging of brains and (C) semi-quantification results of fluorescence of brain tumor tissues 24 h post micelle injection. (D) Biodistribution of Ang-MIC 24 h post micelle injection (n = 3). ^#P < 0.05, **P < 0.01, compared with MIC.