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. 2022 Feb 16;13:902. doi: 10.1038/s41467-022-28428-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Endonuclease (ENDO) and prime-and-realign loop (PR loop) movements between the replication states. ENDO N-terminus (N-ter) and C-terminus (C-ter) are indicated. Arrows indicate movements of the ENDO, the α7 helix, and the PR loop. b LACV-L domain movements and RNA position variations between the replication states. For clarity, only domains that undergo conformational changes are displayed. The template exit plug, colored in red, is indicated with a dotted line if flexible. RNAs are shown as surfaces and colored as in Fig. 1c, d. Bridge residues 1423–1441 are surrounded by a dotted line. c Template exit plug, vRNA binding lobe (vRBL), clamp, and α-ribbon conformational changes between the replication states. LACV-L surface is displayed and each domain is colored as in Figs. 2a, b and 3b. The template exit tunnel is surrounded by a dotted line. Template entry/exit tunnels are indicated in the early-elongation state with gold arrows.