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. 2022 Feb 16;12:2605. doi: 10.1038/s41598-022-06359-5

Figure 2.

Figure 2

Host production of glucocorticoids predicts gut microbiome alpha diversity. (A) Boxplot and line graph showing the opposing relationship between mean fecal glucocorticoid metabolites (GCs, scaled) and median gut microbiome diversity (Chao1 richness) across each month of the three sampling years. Outliers removed from plot for visualization purposes. (B) Partial residual plots (points represent individual samples) showing the relationship between gut microbiome taxonomic richness (Chao1), (C) taxonomic richness and evenness (Shannon Index), and (D) phylogenetic diversity (Faith’s PD) and matched fecal glucocorticoid concentrations (GCs) (N = 227). R2 values (i.e., coefficients of determination) were obtained from linear mixed-effect models.