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. 2022 Feb 16;13(2):156. doi: 10.1038/s41419-022-04602-5

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — CHCHD2 and CHCHD10 mainly suppress the OMA1 activity and inhibit phosphorylation of eIF2A at normal conditions by binding them, and loss of CHCHD2 and CHCHD10 activates OMA1 to cleavage OPA1 and DELE1; at stress conditions (loss of membrane potential), CHCHD2 and CHCHD10 increase and translocate from mitochondria to cytosol to suppress phosphorylation of eIF2A to inhibit ISR.