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. 2022 Feb 16;12:2656. doi: 10.1038/s41598-022-05979-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathological findings in liver; (a) non-treated rats manifesting the typical histological architecture of the liver, (a), (b) gamma rays at dose 6 Gy showing congestion in the portal vein (score 3) (yellow arrow) and dilatation in the bile ducts (D) (score 2), associated with fibrosis (score 2) in the liver. (c) Rats were received of BV 0.05 mg/kg showed there was no histopathological alteration (score 0) as recorded in liver. (d) Rats were administered of propolis 300 mg/kg showed no alteration (score 0) of liver. (e) Effect of combination treatment of propolis + BV 300 & 0.05 mg/kg showed normal histological structure (score 0) in liver. (f–h) Effect of propolis 300 mg/kg and BV 0.05 separately and combined (respectively) on the normal rats for two weeks without any alterations in liver. Normal hepatocytes radiating from the central vein (CV) and separated by blood sinusoids (arrows) (f–h). H&E stain used.