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. 2022 Feb 3;13:821758. doi: 10.3389/fphar.2022.821758

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Copyright © 2022 Isaev, Shabbir, Dinc, Lorke, Petroianu and Oz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cannabidiol inhibits the I _L-Ca in rabbit ventricular myocytes (A) Original current traces elicited by voltages in the range of −50 mV to +50 mV in control conditions (on the left) and after 10 min exposure to 10 μM CBD (on the right). The pulse protocol to evoke I _L-Ca is presented in the inset (B) Current-voltage relations of I _L-Ca in the absence and presence of 10 μM CBD are presented with filled and open circles, respectively (n = 6) (C) Concentration-inhibition curve for CBD suppression of I _L-Ca (n = 5–8).