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. 2022 Feb 3;13:821758. doi: 10.3389/fphar.2022.821758

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Copyright © 2022 Isaev, Shabbir, Dinc, Lorke, Petroianu and Oz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cannabidiol suppresses the I _Ks component of the delayed rectifying I _K (A) Original current traces recorded in control conditions (on the left) and after 10 min exposure to 3 μM CBD (on the right) in rabbit cardiomyocytes. The pulse protocol to activate I _Ks is presented in the inset. Only solid lines in the voltage protocols are presented in current traces. Dotted line indicates 0 mV baseline (B) Current-voltage relations of I _Ks in the absence and presence of 3 μM CBD are presented with filled and open circles, respectively (n = 5) (C) Concentration-inhibition curve for CBD inhibition of I _Ks (n = 4–7).