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. 2022 Feb 3;13:821758. doi: 10.3389/fphar.2022.821758

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Copyright © 2022 Isaev, Shabbir, Dinc, Lorke, Petroianu and Oz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of cannabidiol on the transient outward I _to in rabbit ventricular myocytes (A) Original traces of I _to obtained in response to incremental depolarizations from a holding potential of −80 mV up to +60 mV are presented in controls (on the left) and after 10 min exposure to 10 μM CBD. The pulse protocol to activate I _to is presented in the inset (B) Averages of current-voltage relation of I _to in the absence (filled circles) and presence of CBD (open circles) are presented (n = 6) (C) The effect of increasing CBD concentrations on I _to (n = 4–6).