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. 2022 Feb 3;13:821758. doi: 10.3389/fphar.2022.821758

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Copyright © 2022 Isaev, Shabbir, Dinc, Lorke, Petroianu and Oz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cannabidiol does not have a significant effect on I _K1 (A) Original current traces recorded in control conditions (on the left) and after10 min exposure to 10 μM CBD (on the right) in a rabbit cardiomyocyte. The pulse protocol to evoke I _K1 is presented in the inset (B) Current-voltage relations of I _K1 in the absence and presence of 10 μM CBD are presented with filled and open circles, respectively (n = 6) (C) The effect of increasing CBD concentrations on I _K1 (n = 4–6).