Table 4.

Quantitative myocardial blood flow and ischemic cut-off values of stress MBF assessed by CT-MPI.

References	Equipment	Normal MBF (ml/100 ml/min)	Ischemic MBF (ml/100 ml/min)	Cutoff value (ml/100 ml/min)	Reference standard	Diagnostic accuracy	Sen	Spe	PPV	NPV	Objects (MI, revascularization)
Bamberg et al. (5)	2nd DSCT	104.8 ± 34.0	73.2 ± 26.0	75	FFR ≤ 0.75 + ICA ≥ 85% DS	N/A	N/A	N/A	N/A	N/A	Yes, yes
Greif et al. (19)	2nd DSCT	122.7 ± 34.0	78.7 ± 26.1	75	FFR ≤ 0.80 + ICA ≥ 90% DS	78.2	95.1	74.0	49.3	98.3	Yes, yes
Rossi et al. (20)	2nd DSCT	109	62	78	FFR ≤ 0.75 + ICA ≥ 90% DS	90	88	90	77	95	No, yes
Kono et al. (21)	2nd DSCT	116.3 ± 27	25.6 ± 22.5	103.1	FFR ≤ 0.80	68.1	88.9	47.8	62.5	81.5	No, no
Wichmann et al. (25)	2nd DSCT	140 ± 38.4	80.7 ± 33.7	103	CCTA ≥ 50% DS	62.9	82.4	80.5	60.1	92.8	No, no
Li et al. (12)	3st DSCT	169 ± 34	75 ± 20	99	FFR ≤ 0.80 + ICA ≥ 90% DS	94	96	93	92	96	No, no
Li et al. (22)	3st DSCT	133	78	89.5	FFR ≤ 0.80	90.5	84.3	97.7	97.7	84.3	No, no
Coenen et al. (15)	3st DSCT	108	79	91	MRI	68	75	61	63	73	No, no
Rossi et al. (24)	2nd DSCT	161	92 (74–109)	106	FFR ≤ 0.80 + ICA ≥ 80% DS	N/A	75	88.3	68.3	91.3	No, no
Pontone et al. (23)	Revolution CT	130 ± 46	96 ± 32	101	FFR ≤ 0.80 + ICA ≥ 80% DS	78	86	75	60	93	No, no
Yi et al. (10)	3st DSCT	147.5 ± 25.6	91.5 ± 29.9	N/A	FFR ≤ 0.80 + ICA ≥ 80% DS	92	83	99	98	90	No, no
Current study	3st DSCT	164 ± 24	96 ± 21	116	FFR ≤ 0.75 + ICA ≥ 80% DS	85.9	91.0	83.2	94.8	73.5	No, no

CCTA, Coronary computed tomography angiography; CT-MPI, computed tomography myocardial perfusion imaging; DS, diameter stenosis; DSCT, dual-source CT scanner; FFR, fractional flow reserve; ICA, interventional coronary angiography; MBF, myocardial blood flow; MI, myocardial infarction; NPV, negative predictive value; N/A, not reported; PPV, positive predictive value; Sen, sensitivity; Spe, specificity.