TABLE 4.
Change in trough percentage predicted forced expiratory volume in 1 s (ppFEV1) and lung clearance index (LCI) after 4 weeks of treatment with BI 1265162 (BI) twice daily: all treatment groups (descriptive statistics)
| Trough ppFEV1 (TS) | LCI (N2MBWS) | |||||||
| Patients | Baseline score | Patients | Change from baseline after 4 weeks | Patients | Baseline score | Patients | Change from baseline after 4 weeks | |
| Placebo | 18 | 59.40±11.29 | 17 | –0.60±8.03 | 6 | 13.899±3.581 | 6 | –0.824±3.312 |
| BI 20 µg | 6 | 69.93±15.99 | 4 | –0.50±2.82 | 0 | 0 | ||
| BI 50 µg | 5 | 63.02±14.40 | 5 | –0.22±2.62 | 1 | 14.958±NA# | 1 | –0.238±NA# |
| BI 100 µg | 5 | 65.50±7.00 | 5 | 2.82±3.57 | 1 | 16.223±NA# | 1 | –2.547±NA# |
| BI 200 µg | 17 | 57.94±13.76 | 16 | 0.45±5.42 | 3 | 16.254±1.794 | 3 | –0.081±1.001 |
Data are presented as n or mean±sd. TS: treated set; N2MBWS: nitrogen multiple-breath washout set; NA: not applicable. #: data from only one patient; no standard deviation could be calculated.