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. 2022 Feb 12;76:103880. doi: 10.1016/j.ebiom.2022.103880

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig 1 — The haematoma as a therapeutic target in ICH. The haematoma can cause brain injury via mass effect and the release of potentially toxic, plasma- or erythrocyte-derived factors. Surgical haematoma evacuation and accelerating endogenous haematoma clearance via phagocytosis are potential approaches, as is delaying erythrocyte lysis and inhibiting deleterious effects of clot-derived factors. RBC, red blood cell; MAC, membrane attack complex; Hb, haemoglobin; CA1, carbonic anhydrase 1; Prx2, peroxiredoxin-2; SIRPα, signal regulatory protein alpha.