Table 1.
Demographics of the Translational Biomarkers in Aging and Dementia (TRIAD) cohort.
| CU Aβ- (n = 83) | CU Aβ+ (n = 26) | CI Aβ- (n = 21) | CI Aβ+ (n = 41) | |
|---|---|---|---|---|
| Females | 51 (61) | 17 (65) | 11 (52) | 18 (43) |
| Age (yr) | 55.48 (23.25) | 72.20 (7.54)⁎⁎⁎ | 67.24 (9.91)⁎⁎⁎ | 67.86 (7.88)⁎⁎⁎ |
| Education (yr) | 15.56 (3.15) | 14.42 (2.70) | 14.94 (4.92) | 15.42 (2.98) |
| APOE-ε4 carriers | 23 (27) | 8 (30) | 4 (19) | 27 (67)⁎⁎⁎ |
| MMSE | 29.38 (0.90) | 29.23 (0.86) | 26.76 (2.10)⁎⁎ | 23.82 (6.09)⁎⁎⁎ |
| Aβ PET SUVR | 1.23 (0.10) | 1.96 (0.42)⁎⁎⁎ | 1.25 (0.13) | 2.38 (0.42)⁎⁎⁎ |
| Tau PET SUVR | 0.88 (0.10) | 1.00 (0.15) | 0.85 (0.13) | 1.87 (0.61)⁎⁎⁎ |
| p-tau231 (pg/mL) | 8.71 (3.29) | 22.14 (17.67)⁎⁎⁎ | 9.64 (4.19) | 34.32 (19.86)⁎⁎⁎ |
| p-tau217 (pg/mL) | 4.44 (2.88) | 15.64 (17.63)⁎⁎⁎ | 5.04 (2.30) | 26.79 (16.87)⁎⁎⁎ |
| p-tau181 (pg/mL) | 198.83 (122.47) | 404.70 (213.81)⁎⁎⁎ | 219.96 (91.13) | 806.32 (508.79)⁎⁎⁎ |
Data are mean (SD) or n (%); MMSE Mini-Mental State Examination.
*P values were calculated comparing groups against CU Aβ- subjects using linear regression models for continuous variables and Chi-square tests for categorical variables.
*P<0.05; ⁎⁎⁎P<0.001.