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. 2022 Feb 3;13:830763. doi: 10.3389/fphar.2022.830763

FIGURE 1.

FIGURE 1

DBZ improves cardiac function and attenuates cardiac remodeling in TAC-induced cardiac hypertrophy. (A) Flowchart of study protocol. (B–D) The ratios of heart weight/body weight, heart weight/tibia length, and left ventricular mass/body weight of rats (n = 10) in the 8th week. (E) Representative transverse sections of H&E staining (first row; scale bar = 2 μm), Macroscopic view of H&E staining (second row; scale bar = 50 μm), WGA staining (third row; scale bar = 50 μm) and Masson’s staining (fourth and fifth row; scale bar = 200 and 50 μm) from heart transverse sections. n = 4–6. (F) Representative images of Western blotting assay of BNP. (G–L) Representative M-mode images of the four groups and quantification of interventricular septum diastolic dimension (IVSd), LV internal dimension diastole (LVIDd), and LV posterior wall thickness diastole (LVPWd), ejection fraction (EF) and fractional shortening (FS). n = 6. Results are expressed as means ± SD. Statistical analyses were performed by one-way ANOVA followed by Bonferroni’s post-hoc test.