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. 2022 Feb 3;13:830763. doi: 10.3389/fphar.2022.830763

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Copyright © 2022 Han, Wang, Wang, Qiao, Cui, Zhang, Jiang, Liu, Shangguan, Zheng, Bai, Du and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DBZ attenuated the oxidative stress. (A) Representative images and quantification of DHE staining in transverse sections and quantification. n = 3. (B) Protein levels of NOX4, NOX2 and HO-1 were determined by Western blotting assay and quantified by densitometry. n = 3. (C) The ROS generation measured using DCFH-DA. n = 3. Scale bar = 20 μm. (D,E) Representative Western blotting assay and quantification of NOX4, NOX2 and HO-1 expression. n = 3. *p < .05 compared with the sham group, ^# p < .05 compared with the TAC group, **p < .05 compared with the control group, ^## p < .05 compared with the Ang II group. Results are expressed as means ± SD. Statistical analyses were performed by one-way ANOVA followed by Bonferroni’s post-hoc test.