Fig. 5.

SELENBP1 inhibits tumor angiogenesis in mice. HCT-116 cells stably overexpressing SELENBP1 or vector were inoculated subcutaneously into the right flank of nude mice (n = 5 per group). Tumor growth was monitored twice a week (A). On Day 25 after inoculation, mice were euthanized and tumors were photographed (B). Formalin-fixed and paraffin-embedded tumor blocks were cut into 5 μm sections and stained with an anti-CD31 antibody for MVD quantification (C). Abbreviations: MVD, microvascular density; SELENBP1, selenium binding protein 1. ^⁎⁎⁎⁎p < 0.0001 vs. the control group.