SELENBP1 may inhibits angiogenesis in CRC by suppressing DLL4. HUVECs were transduced with indicated lentiviruses and underwent CCK8 (A), colony formation (B), migration (C), invasion (D), and tube formation (E) assays. Abbreviations: CRC, colorectal cancer; DLL4, Delta-like ligand 4; NS, nonsignificant; SELENBP1, selenium binding protein 1. *p < 0.05; ⁎⁎p < 0.01; ⁎⁎⁎p < 0.001; ⁎⁎⁎⁎p < 0.0001 vs. the control. #p < 0.05; ##p < 0.01; ###p < 0.001; ####p < 0.0001 vs. the control for rescue experiments in the CCK8 assay.