Table 3.
Probability of differences in fitted volumes at −10 and 0 years before death.
| Timescale | Region | First | Second | Median difference | P(First > Second) | P(Second > First) |
|---|---|---|---|---|---|---|
| −10 years prior to death | Amygdala | 65yo FTLD-TDP | 85yo FTLD-TDP | −0.09 | 0.570 | 0.430 |
| 65yo FTLD-TDP | pure-TDP | −0.48 | 0.862 | 0.138 | ||
| 65yo FTLD-TDP | AD-TDP type α | −0.12 | 0.626 | 0.374 | ||
| 65yo FTLD-TDP | AD-TDP type β | −0.91 | 0.990 | 0.010 | ||
| 85yo FTLD-TDP | pure-TDP | −0.39 | 0.803 | 0.197 | ||
| 85yo FTLD-TDP | AD-TDP type α | −0.04 | 0.538 | 0.462 | ||
| 85yo FTLD-TDP | AD-TDP type β | −0.83 | 0.982 | 0.018 | ||
| pure-TDP | AD-TDP type α | 0.35 | 0.130 | 0.870 | ||
| pure-TDP | AD-TDP type β | −0.44 | 0.906 | 0.094 | ||
| AD-TDP type α | AD-TDP type β | −0.80 | >0.999 | <0.001 | ||
| Hippocampus | 65yo FTLD-TDP | 85yo FTLD-TDP | 0.71 | 0.100 | 0.900 | |
| 65yo FTLD-TDP | pure-TDP | 0.06 | 0.454 | 0.546 | ||
| 65yo FTLD-TDP | AD-TDP type α | 0.58 | 0.090 | 0.910 | ||
| 65yo FTLD-TDP | AD-TDP type β | −0.31 | 0.757 | 0.243 | ||
| 85yo FTLD-TDP | pure-TDP | −0.65 | 0.884 | 0.116 | ||
| 85yo FTLD-TDP | AD-TDP type α | −0.13 | 0.608 | 0.392 | ||
| 85yo FTLD-TDP | AD-TDP type β | −1.03 | 0.984 | 0.016 | ||
| pure-TDP | AD-TDP type α | 0.52 | 0.079 | 0.921 | ||
| pure-TDP | AD-TDP type β | −0.37 | 0.819 | 0.181 | ||
| AD-TDP type α | AD-TDP type β | −0.90 | >0.999 | <0.001 | ||
| Temp. Pole | 65yo FTLD-TDP | 85yo FTLD-TDP | 1.39 | 0.013 | 0.987 | |
| 65yo FTLD-TDP | pure-TDP | 0.08 | 0.446 | 0.554 | ||
| 65yo FTLD-TDP | AD-TDP type α | 0.27 | 0.290 | 0.710 | ||
| 65yo FTLD-TDP | AD-TDP type β | −0.21 | 0.656 | 0.344 | ||
| 85yo FTLD-TDP | pure-TDP | −1.32 | 0.982 | 0.018 | ||
| 85yo FTLD-TDP | AD-TDP type α | −1.12 | 0.981 | 0.019 | ||
| 85yo FTLD-TDP | AD-TDP type β | −1.60 | 0.998 | 0.002 | ||
| pure-TDP | AD-TDP type α | 0.19 | 0.332 | 0.668 | ||
| pure-TDP | AD-TDP type β | −0.28 | 0.731 | 0.269 | ||
| AD-TDP type α | AD-TDP type β | −0.48 | 0.935 | 0.065 | ||
| Inf. Temp. | 65yo FTLD-TDP | 85yo FTLD-TDP | 0.54 | 0.146 | 0.854 | |
| 65yo FTLD-TDP | pure-TDP | 0.00 | 0.502 | 0.498 | ||
| 65yo FTLD-TDP | AD-TDP type α | 0.34 | 0.205 | 0.794 | ||
| 65yo FTLD-TDP | AD-TDP type β | −0.19 | 0.672 | 0.328 | ||
| 85yo FTLD-TDP | pure-TDP | −0.55 | 0.868 | 0.132 | ||
| 85yo FTLD-TDP | AD-TDP type α | −0.21 | 0.685 | 0.315 | ||
| 85yo FTLD-TDP | AD-TDP type β | −0.75 | 0.958 | 0.042 | ||
| pure-TDP | AD-TDP type α | 0.34 | 0.159 | 0.841 | ||
| pure-TDP | AD-TDP type β | −0.20 | 0.708 | 0.292 | ||
| AD-TDP type α | AD-TDP type β | −0.53 | 0.984 | 0.016 | ||
| Mid. Front. | 65yo FTLD-TDP | 85yo FTLD-TDP | 0.13 | 0.403 | 0.597 | |
| 65yo FTLD-TDP | pure-TDP | 0.04 | 0.471 | 0.529 | ||
| 65yo FTLD-TDP | AD-TDP type α | 0.24 | 0.286 | 0.714 | ||
| 65yo FTLD-TDP | AD-TDP type β | −0.14 | 0.632 | 0.368 | ||
| 85yo FTLD-TDP | pure-TDP | −0.09 | 0.574 | 0.426 | ||
| 85yo FTLD-TDP | AD-TDP type α | 0.11 | 0.402 | 0.598 | ||
| 85yo FTLD-TDP | AD-TDP type β | −0.27 | 0.734 | 0.266 | ||
| pure-TDP | AD-TDP type α | 0.20 | 0.278 | 0.722 | ||
| pure-TDP | AD-TDP type β | −0.18 | 0.692 | 0.308 | ||
| AD-TDP type α | AD-TDP type β | −0.38 | 0.939 | 0.061 | ||
| 0 years prior to death | Amygdala | 65yo FTLD-TDP | 85yo FTLD-TDP | −0.16 | 0.699 | 0.301 |
| 65yo FTLD-TDP | pure-TDP | −1.98 | >0.999 | <0.001 | ||
| 65yo FTLD-TDP | AD-TDP type α | −0.55 | 0.967 | 0.033 | ||
| 65yo FTLD-TDP | AD-TDP type β | −1.20 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | pure-TDP | −1.82 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | AD-TDP type α | −0.39 | 0.850 | 0.150 | ||
| 85yo FTLD-TDP | AD-TDP type β | −1.03 | 0.997 | 0.003 | ||
| pure-TDP | AD-TDP type α | 1.43 | < 0.001 | >0.999 | ||
| pure-TDP | AD-TDP type β | 0.78 | 0.009 | 0.991 | ||
| AD-TDP type α | AD-TDP type β | −0.65 | 0.995 | 0.005 | ||
| Hippocampus | 65yo FTLD-TDP | 85yo FTLD-TDP | 0.30 | 0.214 | 0.786 | |
| 65yo FTLD-TDP | pure-TDP | −2.28 | >0.999 | <0.001 | ||
| 65yo FTLD-TDP | AD-TDP type α | −0.51 | 0.920 | 0.080 | ||
| 65yo FTLD-TDP | AD-TDP type β | −1.89 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | pure-TDP | −2.58 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | AD-TDP type α | −0.81 | 0.963 | 0.037 | ||
| 85yo FTLD-TDP | AD-TDP type β | −2.19 | >0.999 | <0.001 | ||
| pure-TDP | AD-TDP type α | 1.77 | <0.001 | >0.999 | ||
| pure-TDP | AD-TDP type β | 0.40 | 0.164 | 0.836 | ||
| AD-TDP type α | AD-TDP type β | −1.38 | >0.999 | <0.001 | ||
| Temp. Pole | 65yo FTLD-TDP | 85yo FTLD-TDP | 1.10 | 0.006 | 0.994 | |
| 65yo FTLD-TDP | pure-TDP | −2.70 | > 0.999 | <0.001 | ||
| 65yo FTLD-TDP | AD-TDP type α | −1.09 | 0.996 | 0.004 | ||
| 65yo FTLD-TDP | AD-TDP type β | −1.81 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | pure-TDP | −3.80 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | AD-TDP type α | −2.18 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | AD-TDP type β | −2.90 | >0.999 | <0.001 | ||
| pure-TDP | AD-TDP type α | 1.61 | <0.001 | >0.999 | ||
| pure-TDP | AD-TDP type β | 0.89 | 0.030 | 0.970 | ||
| AD-TDP type α | AD-TDP type β | −0.72 | 0.986 | 0.014 | ||
| Inf. Temp. | 65yo FTLD-TDP | 85yo FTLD-TDP | 0.25 | 0.236 | 0.764 | |
| 65yo FTLD-TDP | pure-TDP | −3.03 | >0.999 | <0.001 | ||
| 65yo FTLD-TDP | AD-TDP type α | −1.37 | >0.999 | <0.001 | ||
| 65yo FTLD-TDP | AD-TDP type β | −1.83 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | pure-TDP | −3.28 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | AD-TDP type α | −1.61 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | AD-TDP type β | −2.07 | >0.999 | <0.001 | ||
| pure-TDP | AD-TDP type α | 1.66 | <0.001 | >0.999 | ||
| pure-TDP | AD-TDP type β | 1.21 | 0.001 | >0.999 | ||
| AD-TDP type α | AD-TDP type β | −0.46 | 0.962 | 0.038 | ||
| Mid. Front. | 65yo FTLD-TDP | 85yo FTLD-TDP | −1.12 | 0.999 | 0.001 | |
| 65yo FTLD-TDP | pure-TDP | −2.54 | >0.999 | <0.001 | ||
| 65yo FTLD-TDP | AD-TDP type α | −2.11 | >0.999 | <0.001 | ||
| 65yo FTLD-TDP | AD-TDP type β | −1.94 | >0.999 | <0.001 | ||
| 85yo FTLD-TDP | pure-TDP | −1.43 | 0.999 | 0.001 | ||
| 85yo FTLD-TDP | AD-TDP type α | −1.00 | 0.992 | 0.008 | ||
| 85yo FTLD-TDP | AD-TDP type β | −0.83 | 0.977 | 0.023 | ||
| pure-TDP | AD-TDP type α | 0.44 | 0.112 | 0.888 | ||
| pure-TDP | AD-TDP type β | 0.61 | 0.054 | 0.946 | ||
| AD-TDP type α | AD-TDP type β | 0.17 | 0.257 | 0.743 |