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. 2022 Feb 3;14:827493. doi: 10.3389/fnagi.2022.827493

FIGURE 2.

FIGURE 2

Correlation analysis of erythrocytic total and oligomeric α-syn concentrations with clinical characteristics in PD. (A) Erythrocytic total α-syn concentrations adjusted by age and sex were significantly correlated with HAMA scales (p = 0.016, r = –0.292) in PD patients. (C) No significant correlations between erythrocytic total α-syn concentrations and HAMD scales (p = 0.140, r = –0.182) were observed in PD patients. (B,D) Erythrocytic oligomeric α-syn concentrations were not correlated with HAMD scales (p = 0.291, r = 0.131) and HAMA scales (p = 0.649, r = 0.057) in PD patients. (E) Significant correlations between MDS-UPDRS III scores and erythrocytic total α-syn levels (p < 0.001, r = 0.455) were found in PD patients. (F) No correlations were found between MDS-UPDRS III scores and erythrocytic oligomeric α-syn levels (p = 0.368, r = 0.107). Dash lines represent 95% confidence intervals. Partial correlation analysis with the controlling of age and sex was used to assess the correlations. α-syn, α-synuclein; HAMA, Hamilton Anxiety Rating Scale; HAMD, 17-item Hamilton Depression Rating Scale; MDS-UPDRS III, Movement Disorder Society sponsored Unified Parkinson’s Disease Rating Scale Part-III; RBC, red blood cell.