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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Transplantation. 2021 Aug 11;106(5):950–962. doi: 10.1097/TP.0000000000003920

Figure 8. Effects of mTOR blockade in preventing xenoreactive T-cell proliferative responses to PEC.

Figure 8.

The primary proliferation of xenoreactive T cells in response to PEC was inhibited dramatically in the presence of mTOR inhibitor rapamycin. PECs, pretreated with rapamycin, are unable to induce xenoreactive T cell proliferative responses. The PD-1/PD ligand-1 blockade with PD-1–specific antibody fails to restore T-cell proliferation in response to rapamycin-pretreated PECs. PD-1 blockade does not inhibit PEC-induced T-cell proliferation.