Table 1.

Number of SARS-CoV-2 cases, COVID-19 deaths, COVID-19 case-fatality rate (deaths/cases*100) in the first (1st) wave (February 24-June 30), and case/infection-fatality rate (deaths/cases*100) in the second (2nd) waves (September 30-December 31) in 2020 divided by province and region. SARS-CoV-2 seroprevalence (%) after the 1st wave (period May-July 2020) and infection-fatality rate (deaths/seroprevalents*100).

Region/Province	Population Jan 1, 2020	Cases 1st wave	Cases 2nd wave	Seroprev. (%)	Deaths 1st wave	Deaths 2nd wave	Case-fatality rate 1st wave	Infection-fatality rate 1st wave	Case/infection fatality rate 2nd wave
Aosta Valley	125501	1195	5771	3.72	145	239	12.1	3.1	4.1
Aosta	125501	1195	5771	3.72	145	239	12.1	3.1	4.1
Lombardy	10103969	91813	368273	7.35	16633	8321	18.1	2.2	2.3
Bergamo	1116384	14375	12873	24.3	3137	193	21.8	1.2	1.5
Brescia	1268455	15626	25468	7.63	2686	422	17.2	2.8	1.7
Como	603828	4093	29531	2.00	587	794	14.3	4.8	2.7
Cremona	358347	6612	7664	19.7	1130	123	17.1	1.6	1.6
Lecco	337087	2831	10303	6.66	481	236	17.0	2.1	2.3
Lodi	230607	3570	6936	7.10	679	140	19.0	4.1	2.0
Mantua	411062	3496	12260	6.57	684	288	19.6	2.5	2.3
Milan	3279944	24379	147720	3.95	4252	3197	17.4	3.3	2.2
Monza/Brianza	878267	5772	42090	4.52	979	895	17.0	2.5	2.1
Pavia	546515	5568	18869	5.95	1241	543	22.3	3.7	2.9
Sondrio	180941	1584	6954	5.30	212	201	13.4	2.2	2.9
Varese	892532	3907	47605	1.71	565	1289	14.5	3.7	2.7
Veneto	4907704	18937	227276	1.92	2028	4960	10.7	2.1	2.2
Belluno	201972	1191	13369	1.88	114	330	9.6	3.0	2.5
Padua	939672	3954	41651	2.32	318	608	8.0	1.5	1.5
Rovigo	233386	444	6932	2.39	36	204	8.1	0.6	2.9
Treviso	888309	2673	45715	1.89	322	783	12.0	1.9	1.7
Venice	851663	2682	35612	1.68	299	863	11.1	2.1	2.4
Verona	930339	5127	44073	2.23	586	1195	11.4	2.8	2.7
Vicenza	862363	2866	39924	1.33	353	977	12.3	3.1	2.4
Emilia-Romagna	4467118	28061	137052	2.90	4353	3431	15.5	3.4	2.5
Bologna	1017806	5229	32314	2.33	732	936	14.0	3.0	2.9
Ferrara	344840	1044	7886	0.72	173	222	16.6	7.0	2.8
Forlì-Cesena	394833	1740	10213	1.04	196	164	11.3	4.8	1.6
Modena	707292	3873	25945	1.10	480	601	12.4	6.2	2.3
Parma	453930	3657	8701	5.84	901	215	24.6	3.4	2.5
Piacenza	287236	4428	10187	9.54	956	252	21.6	3.5	2.5
Ravenna	389634	1030	11337	1.18	81	430	7.9	1.8	3.8
Reggio nell’Emilia	531751	4913	18248	4.45	581	306	11.8	2.5	1.7
Rimini	339796	2147	12221	2.79	253	305	11.8	2.9	2.5
Piedmont	4341375	30989	162730	3.45	4029	3537	13.0	2.7	2.2
Alessandria	419037	4063	13240	2.08	659	470	16.2	7.7	3.5
Asti	213216	1874	7960	2.13	249	217	13.3	5.5	2.7
Biella	174384	1046	5748	6.59	194	112	18.5	1.7	1.9
Cuneo	586568	2862	24081	0.87	373	494	13.0	7.3	2.1
Novara	368040	2792	12443	5.21	367	272	13.1	1.9	2.2
Turin	2252379	15889	87788	3.58	1844	1712	11.6	2.3	2.0
Verbano-Cusio-Ossola	157455	1140	5515	9.05	132	122	11.6	0.9	2.2
Vercelli	170296	1323	5955	3.52	211	138	15.9	3.5	2.3
Trentino-South Tyrol	1074819	7502	43303	3.19	693	1041	9.2	2.0	2.4
Bolzano	532080	2639	26559	2.95	288	504	10.9	1.8	1.9
Trento	542739	4863	16744	3.42	405	537	8.3	2.2	3.2
Friuli-Venezia Giulia	1211357	3308	45651	1.02	362	1426	10.9	2.9	3.1
Gorizia	139206	216	5904	0.12	5	104	2.3	-†	1.8
Pordenone	312619	702	9792	1.88	68	291	9.7	1.2	3.0
Trieste	233276	1393	9107	0.59	209	270	15.0	-†	3.0
Udine	526256	997	20848	0.93	80	761	8.0	1.6	3.7
Liguria	1543127	9473	46958	3.24	1563	1276	16.5	3.1	2.7
Genoa	835829	5573	29304	3.61	943	853	16.9	3.1	2.9
Imperia	213919	1494	4806	2.39	231	79	15.5	4.5	1.6
La Spezia	219196	860	7142	1.89	159	189	18.5	3.8	2.6
Savona	274183	1546	5706	3.83	230	155	14.9	2.2	2.7
Tuscany	3722729	9779	108429	0.90	1088	2491	11.1	3.3	2.3
Arezzo	341766	676	9779	1.23	47	168	7.0	1.1	1.7
Florence	1004298	3192	29864	0.53	401	839	12.6	7.5	2.8
Grosseto	220785	396	3708	1.18	28	73	7.1	1.1	2.0
Livorno	333509	477	8079	0.56	62	195	13.0	3.3	2.4
Lucca	388678	1351	11010	0.42	151	192	11.2	9.3	1.7
Massa and Carrara	193934	1051	6442	0.00	153	179	14.6	-‡	2.8
Pisa	422310	930	15667	1.55	91	341	9.8	1.4	2.2
Pistoia	293059	747	9640	0.96	76	199	10.2	2.7	2.1
Prato	258152	532	9790	1.02	47	203	8.8	1.8	2.1
Siena	266238	427	4450	2.17	32	102	7.5	0.6	2.3
Umbria	880285	1385	26064	0.67	80	530	5.8	1.4	2.0
Perugia	655403	1008	19843	0.71	51	369	5.1	1.1	1.9
Terni	224882	377	6221	0.55	29	161	7.7	2.4	2.6
Marches	1518400	6549	33194	2.59	987	720	15.1	2.5	2.2
Ancona	469750	1875	9711	2.16	218	185	11.6	2.1	1.9
Ascoli Piceno	206363	290	4790	4.95	12	125	4.1	0.1	2.6
Fermo	173004	473	4337	2.16	67	69	14.2	1.0	1.6
Macerata	312146	1154	7851	2.16	145	159	12.6	2.2	2.0
Pesaro and Urbino	357137	2757	6505	4.95	545	182	19.8	3.1	2.8
Lazio	5865544	8010	148533	1.00	863	2815	10.8	1.4	1.9
Frosinone	485241	663	12990	0.19	79	162	11.9	8.6	1.2
Latina	576655	607	13625	0.50	44	294	7.2	1.5	2.2
Rieti	154232	411	4565	3.00	41	149	10.0	0.9	3.3
Rome	4333274	5872	108988	1.05	672	2016	11.4	1.4	1.8
Viterbo	316142	457	8365	1.52	27	194	5.9	0.6	2.3
Abruzzo	1305770	3261	31124	1.29	461	794	14.1	2.7	2.6
Chieti	383189	818	6284	1.40	131	136	16.0	2.4	2.2
L’Aquila	296491	225	10604	0.54	11	350	4.9	0.7	3.3
Pescara	318678	1586	5447	1.69	239	116	15.1	4.4	2.1
Teramo	307412	632	8789	1.48	80	192	12.7	1.8	2.2
Molise	302265	426	5971	0.81	28	175	6.6	1.1	2.9
Campobasso	218679	364	3829	0.66	22	110	6.0	1.4	2.9
Isernia	83586	62	2142	1.19	6	65	9.7	0.6	3.0
Campania	5785861	4648	182462	0.89	517	2915	11.1	1.0	1.6
Avellino	413926	552	8289	0.00	62	143	11.2	-‡	1.7
Benevento	274080	209	4423	0.00	19	137	9.1	-‡	3.1
Caserta	922171	543	33741	1.48	53	540	9.8	0.4	1.6
Naples	3082905	2652	111294	1.04	314	1811	11.8	1.0	1.6
Salerno	1092779	692	24715	0.31	69	284	10.0	2.1	1.1
Apulia	4008296	4502	84951	0.88	566	2037	12.6	1.6	2.4
Bari	1249246	1491	33237	1.50	153	636	10.3	0.8	1.9
Barletta-Andria-Trani	388390	380	10058	0.77	66	295	17.4	2.2	2.9
Brindisi	390456	659	5795	0.85	67	100	10.2	2.0	1.7
Foggia	616310	1170	18639	1.02	161	655	13.8	2.6	3.5
Lecce	791122	521	6420	0.01	85	114	16.3	-†	1.8
Taranto	572772	281	10802	0.67	34	237	12.1	0.9	2.2
Basilicata	556934	400	10055	0.72	36	214	9.0	0.9	2.1
Potenza	360936	189	6739	0.83	27	156	14.3	0.9	2.3
Matera	195998	211	3316	0.50	9	58	4.3	0.9	1.7
Calabria	1924701	1179	22191	0.51	129	368	10.9	1.3	1.7
Catanzaro	354851	214	3134	0.40	31	49	14.5	2.2	1.6
Cosenza	700385	468	6676	0.78	48	176	10.3	0.9	2.6
Crotone	170718	119	2065	0.11	10	35	8.4	5.2	1.7
Reggio di Calabria	541278	294	8586	0.18	29	81	9.9	3.1	0.9
Vibo Valentia	157469	84	1730	1.12	11	27	13.1	0.6	1.6
Sicily	4968410	3056	89352	0.37	342	2390	11.2	1.9	2.7
Agrigento	429611	135	3651	0.19	24	107	17.8	3.0	2.9
Caltanissetta	260779	186	3733	0.00	18	81	9.7	-‡	2.2
Catania	1104974	779	26464	0.26	103	849	13.2	3.6	3.2
Enna	162368	438	2866	0.00	34	76	7.8	-‡	2.7
Messina	620721	474	10246	0.32	59	136	12.4	2.9	1.3
Palermo	1243328	500	24929	0.89	43	665	8.6	0.4	2.7
Ragusa	321215	87	6490	0.30	6	161	6.9	0.6	2.5
Siracusa	397037	321	5112	0.14	47	162	14.6	8.8	3.2
Trapani	428377	136	5861	0.00	8	153	5.9	-‡	2.6
Sardinia	1630474	1366	28920	0.50	145	712	10.6	1.8	2.5
Cagliari	430914	253	6573	0.38	19	161	7.5	1.2	2.4
Nuoro	206843	78	6055	0.24	12	123	15.4	2.4	2.0
Oristano	156078	61	2416	0.43	8	51	13.1	1.2	2.1
Sassari	489634	875	8997	0.78	90	247	10.3	2.4	2.7
South Sardinia	347005	99	4879	0.42	16	130	16.2	1.1	2.7
Italy	60244639	235839	1808260	2.49	35048	40392	14.9	2.2	2.2

^†Provinces excluded due to implausible data of seroprevalences since the estimated number of seroprevalent subjects are less than the number of positive cases at the end of the first wave. ^‡Provinces excluded due to missing/null data about seroprevalence.