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. 2022 Feb 3;13:830791. doi: 10.3389/fphar.2022.830791

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Copyright © 2022 Liao, Li, Huang, Yu, Chen, Gan, Xiao, Xiang, Ding, Jiang, Li and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tissue distribution of HSK3486 in rats following bolus injection (n = 6 for each point). Twenty four SD rats were randomly assigned to 4 groups, 3/sex/group and dosed 2 mg/kg HSK3486 by bolus injection. Dosed volume was 5 ml/kg. 4, 20, 60 and 240 min after administration, rats were sacrificed and whole blood, as well as brain, heart, liver, lung, kidney, bladder, pancreas, testis, ovarian, uterus, stomach, duodenum, adrenal gland, skin (belly), skeleton muscle and fat were collected. Plasma was prepared from collected whole blood. HSK3486 concentration were quantitatively determined by validated LC/MS/MS method.