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cGAS-STING signaling pathway and senescence. In senescent cells, degraded LaminB1 leads to nuclear membrane damage and chromatin fragments leaking into cytoplasm, which induces the release of SASP by activation of cGAS-STING-IFN pathway. TREX1 and Dnase2 enzymes are down-regulated in senescent cells, contributing to the accumulation of nuclear DNA in cytosol.
