Fig. 2.

Dose-probability of DLT relationship based on the prior model For each dose, the assessed integrated probability of DLT rate has been summarized a using box plot. Grey boxes indicate the interquartile range and whiskers provide the minimum and maximum values. Each candidate dose (on the x-axis) has then a given probability of being underdosing, in the target range of DLT or overdosing based on the position of this distribution in regard to the toxicity thresholds. Horizontal green and red lines correspond respectively to the probability thresholds for Target (0.20) and Overdosing intervals (0.35). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)