Fig. 5.

Predictive posterior probability obtained from the ED-EWOC model for each dose to fall in the pre-specified toxicity categories: (i) under-dosing (blue), (ii) target toxicity (green), (iii) overdosing (red), after the cohort 3 completion. As seen in Fig. 4 (dose-DLT rate relationship), the uncertainty in the DLT rate translates into a probability for each dose to fall in the pre-specified toxicity categories. To report these probabilities, a barplot is provided for each dose keeping colors consistent with Fig. 4. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)