Figure 1.

Representative images of test-article-related DRG and spinal cord findings

(A) Normal lumbosacral DRG in an AAV9.Null-vector-treated animal. (B) Lumbosacral DRG with increased cellularity and dorsal nerve root with degeneration and increased cellularity is shown. (C) Lumbosacral DRG with increased cellularity and degenerating neurons (arrows) is shown. (D) Lumbosacral DRG showing increased cellularity as well as glial cell hyperplasia and hypertrophy (arrows), also referred to as Nageotte nodules is shown. (E) Normal lumbar spinal cord dorsal tracts are shown. (F) Dorsal tract degeneration in the lumbar spinal cord is observed as increased clear space and cellularity. (G) Higher magnification of dorsal tract degeneration in the lumbar spinal cord is shown. (H) Gliosis in the ventral horn of the lumbar spinal cord (arrow) is shown. (I) Higher magnification of gliosis surrounding a neuron in the ventral horn of the lumbar spinal cord (arrow). The scale bars represent 100 μm in all images.