Table 1.

Data summary of the five top ETV6 modulators

	Gene symbol		AKIRIN1	COMMD9	DYRK4	JUNB	SRP72
	shRNA		TRCN0000134954	TRCN0000167758	TRCN0000197116	TRCN0000014943	TRCN0000151445
Genome-wide shRNA screen	Pool		12	11	13	2	15
	Normalized counts	T14	2822	1196	5864	178	5250
		T28	1563	1538	15,253	1131	14,583
		T28 BlastS	41,303	16,880	56,508	9936	163,516
		T42	1306	1835	14,864	656	17,490
		T42 BlastS	24,629	27,894	37,829	12,352	199,618
	∑BlastS-ØBlastS counts		63,063	41,401	64,221	20,500	331,062
	T14 corrected ratio		22.35	34.61	10.95	115.39	63.06
Targeted sequencing validation	KD efficiency (remaining expression)		38.73%	18.78%	26.84%	19.44%	48.82%
	Number of overexpressed targets (≥1 SD)		15	10	16	11	10
	Mean targets relative expression	SD corrected	4.35	2.73	6.03	1.67	2.85
		Ratio	2.10	1.93	3.21	1.99	2.55
	Mean controls relative expression	SD corrected	−1.07	−1.13	−0.76	−1.04	−0.15
		Ratio	0.78	0.71	0.77	0.76	0.93
	Student’s t test p value	Targets vs no targets	0.00133	0.00127	0.00106	0.00129	0.00434
		Targets SHC vs shRNA (paired)	0.00669	0.01284	0.00281	0.02227	0.00564

T14, T28, and T42 represent the timepoints (days after transduction), KD, knockdown; SD, standard deviation.