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. 2022 Jan 29;25(2):103836. doi: 10.1016/j.isci.2022.103836

Figure 4.

Figure 4

Tetraspanin-24, kindlin-2, CILP, and integrin-α10 at the human MTJ

All images are from 10-μm thick sections of human semitendinosus muscle/tendon tissue from patients with ACL. Muscle fibers “M” and tendon “T” meet at the myotendinous junction (MTJ), stained with collagen XXII.

(A) Strong tetraspanin-24 (CD151) signal at the MTJ on the muscle side of collagen XXII and the laminin-γ1 (LAMC1)-stained basement membrane.

(B) Strong kindlin-2 (FERMT2) signal at the MTJ on the muscle side of collagen XXII and the merosin (LAMA2) stained basement membrane.

(C) Strong CILP (cartilage intermediate layer protein 1) signal at the MTJ on the muscle side of collagen XXII in close association with the dystrophin (DMD)-stained sarcolemma.

(D) Strong integrin-α10 signal at the MTJ in close proximity with collagen XXII. The dotted line boxes indicate areas imaged at higher magnification. Scale bars are 50 μm.