Figure 7.

Expression of cachexia markers at the primary tumor site. Re-analysis of Steele et al.'s single cell dataset (Steele et al., 2020) of 16 samples isolated from human PDA patients and 3 adjacent normal pancreas samples (A). All normal and tumor cells combined can be roughly divided into two groups, either neoplastic cells (Epcam⁺) or immune cells (CD45⁺) (B). Differential gene expression in epithelial/tumor cells (left) and immune cells (right) between pancreatic tumor cells and normal pancreatic cells as obtained from the single cell dataset visualized with volcano plots (C). Featureplots showing the induction of genes in pancreatic tumors linked to endothelial inflammation, myeloid cells and cell stress (D). Featureplots showing abundant expression of cachexia mediators in pancreatic tumors (E).