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Proposed mechanism
Stimulation with growth factors such as PDGF induces spatial distribution of Abi1, which facilitates the activation of the Jak2/STAT3 pathway. The association of Abi1 with Jak2 renders the receptor in active state. Abi1 is upregulated in ∼50% of asthmatic airway smooth muscle cultures, promoting the activation of Jak2 and STAT3, hyperplasia, and airway smooth muscle (ASM) thickening.
