Table 1.

Inclusion and exclusion criteria for screening of full texts.

Criterion	Inclusion	Exclusion
Population	Adolescents (9-21 years)	Adults; particular risk groups (eg, men who have sex with men, drug users, sex workers); sexually transmitted infection/HIV-positive persons
Study design	Empirical study including an evaluation of a serious game	Studies of theoretical nature only with no empirical data
Type of study	All published studies, identifiable via PubMed or Web of Science Abstract must be available	Books; all forms of grey literature, including conference abstracts, commentaries, presentations, proceedings, regulatory data, unpublished trial data, government publications, dissertations/theses, journalistic interviews, policy reports as well as any other nonscientific material No abstract available
Focus of study	Sexually transmitted infections Comprehensive sex education or HIV/ sexually transmitted infection prevention	Nonsexually transmitted Noncomprehensive sexuality education or HIV/sexually transmitted infection prevention Other aspects in a broader sense of sexual health (eg, sexual violence, sexual dysfunction, use of antiviral therapy or HIV pre-exposure prophylaxis) not related to sexually transmitted infection prevention in the general population using digital technologies
Role of digital serious game	Digital serious games (including all digital games for learning purposes)	No use of digital serious games Analogous serious games or gamification approaches
Language of publication	English and German	All other languages other than English or German
Date of publication	January 2009 to March 2021	Before 2009