Table 2. Pairwise Logistic Regression Analyses for Alzheimer Diseasea and Related Dementia (ADRD) Diagnoses on Neuropsychiatric Inventory Questionnaire (NPIQ) Domain Scoresb During Follow-up.
| Diagnosis | OR (95% CI) | ||||||
|---|---|---|---|---|---|---|---|
| ADb | LBDb | CAAb | CVDb | FTLDb | HSb | NPb | |
| Delusions | 3.04 (2.34-3.95)c | 1.59 (1.29-1.96)c | 1.85 (1.48-2.30)c | 1.01 (0.81-1.27) | 0.54 (0.40-0.73)c | 1.56 (1.18-2.07)c | 0.43 (0.27-0.69)c |
| Hallucinations | 3.49 (2.55-4.79)c | 2.20 (1.74-2.77)c | 1.77 (1.38-2.26)c | 0.84 (0.65-1.09) | 0.34 (0.23-0.51)c | 1.17 (0.84-1.63) | 0.52 (0.31-0.86)c |
| Agitation/aggression | 1.88 (1.52-2.33)c | 1.22 (1.0-1.49) | 1.72 (1.41-2.1)c | 1.16 (0.94-1.44) | 0.67 (0.52-0.86)c | 1.65 (1.24-2.20)c | 0.67 (0.46-0.96) |
| Dysphoria/depression | 1.40 (1.13-1.73)c | 1.41 (1.15-1.72)c | 1.14.(0.94-1.39) | 1.21 (0.98-1.50) | 0.90 (0.70-1.16) | 1.08 (0.82-1.43) | 0.71 (0.50-1.02) |
| Anxiety | 2.30 (1.85-2.87)c | 1.46 (1.19-1.80)c | 1.64 (1.34-2.01)c | 1.18 (0.95-1.46) | 0.66 (0.51-0.86)c | 1.22 (0.92-1.62) | 0.39 (0.27-0.57)c |
| Euphoria/elation | 1.35 (0.99-1.84) | 1.05 (0.80-1.39) | 1.21 (0.91-1.61) | 1.12 (0.82-1.53) | 0.98 (0.69-1.38) | 1.39 (0.95-2.02) | 0.64 (0.37-1.12) |
| Apathy | 1.6 (1.27-2.01)c | 1.31 (1.05-1.63)c | 1.33 (1.07-1.64)c | 1.08 (0.86-1.35) | 1.50 (1.12-2.03)c | 2.60 (1.86-3.66)c | 0.49 (0.33-0.73)c |
| Disinhibition | 1.37 (1.11-1.70)c | 1.05 (0.87-1.28) | 1.14 (0.93-1.38) | 1.09 (0.88-1.34) | 0.98 (0.76-1.26) | 2.15 (1.63-2.84)c | 0.64 (0.44-0.92)c |
| Irritability/lability | 1.71 (1.38-2.12)c | 1.06 (0.86-1.29) | 1.46 (1.20-1.79)c | 1.29 (1.04-1.60)c | 0.75 (0.58-0.96)c | 1.46 (1.10-1.95)c | 0.53 (0.37-0.77)c |
| Aberrant motor behavior | 1.81 (1.44-2.26)c | 1.19 (0.97-1.46) | 1.29 (1.05-1.58)c | 1.02 (0.82-1.26) | 0.95 (0.73-1.24) | 2.08 (1.56-2.76)c | 0.55 (0.37-0.81)c |
| Sleep/nighttime behaviors | 1.22 (0.99-1.52) | 1.41 (1.15-1.73)c | 1.28 (1.05-1.56)c | 1.17 (0.94-1.46) | 0.93 (0.72-1.21) | 1.42 (1.07-1.90)c | 0.75 (0.52-1.08) |
| Appetite/eating disturbances | 1.06 (0.86-1.32) | 1.12 (0.91-1.36) | 1.11 (0.91-1.36) | 1.11 (0.90-1.37) | 1.04 (0.80-1.34) | 1.29 (0.97-1.70) | 0.77 (0.53-1.11) |
Abbreviations: AD, Alzheimer disease (defined as intermediate or high ABC criteria); CAA, cerebral amyloid angiopathy; CVD, cerebrovascular disease; FTLD, frontotemporal lobar degeneration; HS, hippocampal sclerosis; LBD, Lewy body disease; NP, no known pathology; OR, odds ratio.
a
Defined as intermediate or high ABC criteria.
b
Defined as ever present or always absent.
c
P < .05 after multiple comparison correction to control for false discovery rate.