Table 3. Multiple Logistic Regression of Neuropathology Subtypes on Neuropsychiatric Inventory Questionnaire (NPIQ) Domain Scores During Follow-up (N = 1672)a.
| Diagnosis | OR (95% CI) | ||||||
|---|---|---|---|---|---|---|---|
| AD | LBD | CAA | CVD | FTLD | HS | NP | |
| Delusions | 2.78 (1.96-3.94)b | 1.31 (1.04-1.64) | 1.16 (0.89-1.52) | 1.12 (0.88-1.42) | 0.86 (0.61-1.21) | 1.63 (1.21-2.21)b | 1.19 (0.65-2.15) |
| Hallucinations | 3.13 (2.03-4.82)b | 1.81 (1.4-2.33)b | 0.98 (0.73-1.33) | 0.95 (0.72-1.26) | 0.61 (0.39-0.95) | 1.14 (0.8-1.62) | 1.22 (0.6-2.48) |
| Agitation/aggression | 1.57 (1.18-2.1)b | 1.07 (0.86-1.33) | 1.36 (1.06-1.74) | 1.25 (0.99-1.57) | 0.83 (0.62-1.13) | 1.8 (1.33-2.44)b | 1.11 (0.69-1.78) |
| Dysphoria/depression | 1.38 (1.04-1.83) | 1.35 (1.09-1.68)b | 0.96 (0.75-1.22) | 1.18 (0.94-1.48) | 1.06 (0.79-1.42) | 1.11 (0.83-1.48) | 0.97 (0.61-1.55) |
| Anxiety | 1.82 (1.36-2.43)b | 1.24 (0.99-1.55) | 1.07 (0.83-1.37) | 1.14 (0.9-1.44) | 0.78 (0.58-1.05) | 1.24 (0.91-1.67) | 0.59 (0.37-0.96) |
| Euphoria/elation | 1.32 (0.85-2.06) | 1.01 (0.75-1.36) | 1.03 (0.72-1.47) | 1.06 (0.76-1.48) | 0.98 (0.64-1.51) | 1.36 (0.91-2.01) | 0.83 (0.41-1.69) |
| Apathy | 1.7 (1.24-2.31)b | 1.23 (0.97-1.56) | 1.07 (0.82-1.4) | 1.09 (0.85-1.39) | 1.82 (1.29-2.57)b | 2.7 (1.89-3.85)b | 0.92 (0.56-1.53) |
| Disinhibition | 1.46 (1.09-1.95) | 0.96 (0.77-1.18) | 0.91 (0.71-1.16) | 1.13 (0.9-1.41) | 1.09 (0.81-1.47) | 2.17 (1.62-2.90)b | 0.88 (0.55-1.42) |
| Irritability/lability | 1.48 (1.11-1.98)b | 0.89 (0.72-1.11) | 1.13 (0.88-1.44) | 1.34 (1.06-1.69) | 0.88 (0.65-1.18) | 1.48 (1.09-2.01) | 0.68 (0.42-1.09) |
| Aberrant motor behavior | 1.94 (1.42-2.64)b | 1.1 (0.88-1.37) | 0.92 (0.72-1.19) | 1.06 (0.84-1.34) | 1.25 (0.91-1.70) | 2.22 (1.65-3.00)b | 0.88 (0.53-1.46) |
Abbreviations: AD, Alzheimer disease (defined as intermediate or high ABC criteria); CAA, cerebral amyloid angiopathy; CVD, cerebrovascular disease; FTLD, frontotemporal lobar degeneration; HS, hippocampal sclerosis; LBD, Lewy body disease; NP, no known pathology; OR, odds ratio.
a
All regression analyses were adjusted for age at death, sex, and difference in years between NPIQ assessment and death.
b
P < .05 after multiple comparisons correction to control for false discovery rate.