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. 2022 Feb 3;9:752053. doi: 10.3389/fcell.2021.752053

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Copyright © 2022 Kang, Chen, Xin, Liu, Ma, Ren, Ji, Yu, Qu, Wang, Liu, Xiang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA sequencing analysis of kidneys from C57BL/6J mice treated with 15 mg/kg cisplatin. (A) Venn diagram showing the numbers of significant DEGs across the four indicated groups. (B,C) The top 15 enriched GO terms and KEGG pathways of the 2,238 DEGs. (D) Heatmap showing the TNF pathway-related DEGs differentially expressed across the four groups. The colors indicate the value of log10 CPM. CPM, counts per million; cisplatin, Cis-diamminedichloroplatinum (II); DEGs, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.