TABLE 1.
Representative DEGs identified by RNA sequencing in cisplatin + hAECs or cisplatin + EXOs compared with cisplatin-treated tumors.
| Gene | Cisplatin + hAECs vs. cisplatin | Cisplatin + EXOs vs. cisplatin | ||
|---|---|---|---|---|
| Log2 FC | P adj | Log2 FC | P adj | |
| Adam8 | 2.9686 | 3.31 × 10–9 | 0.8359 | 3.31 × 10–9 |
| Bax | 1.5060 | 3.78 × 10–16 | 0.5605 | 3.78 × 10–18 |
| Bcl3 | 3.0509 | 1.27 × 10–32 | 2.0370 | 1.27 × 10–32 |
| Brca1 | 1.9357 | 5.31 × 10–5 | 1.7134 | 5.31 × 10–5 |
| Bzw2 | 0.5356 | 0.045483 | 0.5295 | 0.045483 |
| Cbr1 | 1.9998 | 1.67 × 10–44 | 0.5610 | 1.67 × 10–44 |
| Ccnb1 | 3.1586 | 0.017644 | 0.8020 | 0.017644 |
| Cdc6 | 1.9437 | 0.021621 | 1.6689 | 0.021621 |
| Cdca3 | 1.3727 | 0.015941 | 1.0782 | 0.015941 |
| Cdca7 | 1.8503 | 0.014304 | 0.6242 | 0.014304 |
| Cdk1 | 1.7407 | 0.000477 | 0.8007 | 0.000477 |
| Cldn4 | 2.7803 | 9.10 × 10–38 | 1.0485 | 9.14 × 10–38 |
| Clspn | 2.5574 | 0.000734 | 1.7433 | 0.000734 |
| Ddias | 3.6595 | 3.69 × 10–22 | 1.1992 | 3.69 × 10–22 |
| Dlgap5 | 2.5165 | 0.007954 | 0.9324 | 0.007954 |
| Esco2 | 2.5888 | 0.000955 | 1.9327 | 0.000955 |
| Fignl1 | 2.3678 | 0.001049 | 0.8020 | 0.001049 |
| Gins2 | 1.5373 | 0.001835 | 1.3674 | 0.001835 |
| Havcr1 | 9.3847 | 1.18 × 10–91 | 1.8328 | 1.18 × 10–91 |
| Irf7 | 4.0488 | 4.41 × 10–162 | 0.9286 | 4.41 × 10–162 |
| Lif | 5.1139 | 3.86 × 10–24 | 0.6457 | 3.86 × 10–24 |
| Mcm3 | 1.0524 | 0.001352 | 2.3359 | 0.001352 |
| Nek6 | 1.5931 | 1.73 × 10–13 | 0.7183 | 1.73 × 10–13 |
| Nupr1 | 1.0746 | 0.000120 | 0.9035 | 0.000120 |
| Psrc1 | 5.6203 | 1.56 × 10–8 | 1.6411 | 1.56 × 10–8 |
| Zbp1 | 2.6423 | 4.04 × 10–10 | 2.5706 | 4.04 × 10–10 |
| Zmat3 | 1.4787 | 4.50 × 10–19 | 1.5122 | 4.50 × 10–19 |
Note. DEGs, differentially expressed genes; cisplatin, Cis-diamminedichloroplatinum (II); hAECs, human amniotic epithelial cells; EXOs, exosomes.