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. 2022 Feb 7;119(7):e2112630119. doi: 10.1073/pnas.2112630119

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Copyright © 2022 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Intraplantar injection of Mg1a in mice caused long-lasting hypersensitivity. (A) Spontaneous pain-behavior counts for 30 min following i.pl. injection of rMg1a (200 pmol) or saline. Data are mean ± SEM (n = 6 per group). (B) Sum of pain-behavior counts at 30 min after i.pl. injection of 200 pmol rMg1a. Data are mean ± SEM (n = 6 per group). ns, not significant. (C) Paw-withdrawal threshold to mechanical stimulus. Data are mean ± SEM (n = 6 per group). **P < 0.01, ***P < 0.001, ****P < 0.0001, two-way ANOVA, Šídák’s multiple comparisons. Note: The x axis is nonlinear. (D) Paw-withdrawal threshold to thermal stimulus. Data are mean ± SEM (n = 6 per group). *P < 0.05, ***P < 0.001, two-way ANOVA, Šídák’s multiple comparisons. Note: The x axis is nonlinear. (E) Paw thickness (ipsilateral/contralateral) measured 3 d after i.pl. injection of 200 pmol rMg1a. Data are mean ± SEM (n = 6 per group).