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. Author manuscript; available in PMC: 2022 Feb 17.
Published in final edited form as: Mol Pharm. 2018 Nov 12;15(12):5454–5467. doi: 10.1021/acs.molpharmaceut.8b00515

Table 2.

Average Pharmacokinetic Parameters after Intravenous Administration of Ibuprofen from References 15, 16, and 17a

parameter value parameter value
k10 (1/h) (1/h) 0.79 k10 (1/h) 0.63
k12 (1/h) 2.79 V (L) 7.51
k21 (1/h) 3.73 CL (L/h) 4.66
Vc (L) 5.23
CL (L/h) 4.06
two-compartment parameters one-compartment parameters
a

k10: elimination rate constant from central compartment; k12 and k21: access and return from peripheral compartment rate constants, respectively; V: distribution volume; Vc: central compartment distribution volume; CL: plasma clearance.