Table 2.
Calculated AUCs for All Five Formulations of Paclitaxel in All Analyzed Tissuesa
| AUC0-INF mean (SD), h·ng/mL |
|||||
|---|---|---|---|---|---|
| solvent-based paclitaxel (pac-T) |
nab-Paclitaxel (nab-P) | mouse albumin nab-paclitaxel (m-nab-P) |
micellar paclitaxel (pac-P) |
polymeric nanoparticle paclitaxel (pac-G) |
|
| plasma | 10847.53 (232.50) | 2492.37b (276.25) | 2447.38b (144.51) | 3328.42b (276.29) | 3056.56b (105.36) |
| blood | 5566.50 (151.76) | 1904.76b (415.36) | 1326.57b (79.16) | 2325.94b (245.58) | 1983.00b (84.41) |
| liver | 71,131.52 (4952.55) | 56,570.81b (5351.94) | 64,023.61 (1579.83) | 99,394.93b (9391.88) | 75,974.15 (7994.15) |
| stomach | 21,813.99 (972.27) | 17,543.62b (2064.45) | 20,508.37 (1451.79) | 24,321.27 (1705.92) | 19,772.03 (1175.46) |
| muscle | 7122.72 (573.73) | 6165.92 (613.50) | 6282.92 (294.81) | 8279.61 (487.70) | 6931.53 (815.18) |
| skin | 10,150.87 (339.49) | 8505.55 (1271.54) | 7405.45b (579.95) | 11,268.54 (978.75) | 8325.44b (749.37) |
| fat | 3328.60 (422.81) | 2029.48b (49.73) | 3887.34 (266.34) | 5713.56b (93.69) | 4406.78 (689.27) |
| spleen | 15,840.13 (1063.73) | 11,864.65b (2061.66) | 12,850.25b (858.92) | 17,945.36 (1528.89) | 14,126.55 (815.05) |
| lung | 18,851.56 (1492.11) | 12,378.56b (2359.01) | 11,655.31b (513.80) | 16,063.07b (412.86) | 14,147.04b (430.56) |
| brain | 152.84 (25.23) | 91.29 (34.76) | 239.38b (38.57) | 290.32 (122.14) | 195.07 (49.28) |
| uterus | 23,121.74 (5187.14) | 15,543.08 (2837.44) | 13,297.48b (2400.04) | 18,185.78 (5111.12) | 15,638.86 (1821.37) |
| intestine | 34,134.64 (5792.73) | 29,289.10 (2482.30) | 24,402.88b (1360.68) | 39,446.21 (4378.35) | 32,754.36 (969.64) |
| pancreas | 27,975.06 (409.81) | 20,678.54b (1466.13) | 21,803.74b (934.24) | 16,965.35b (576.41) | 16,522.33b (1498.12) |
| kidney | 22,941.88 (1238.78) | 15,602.01b (1425.70) | 17,836.97b (834.99) | 22,770.56 (1664.14) | 20,321.29 (1815.81) |
| fat pad | 5263.13 (97.00) | 4013.45b (286.08) | 4772.09 (554.54) | 6955.02b (392.75) | 5408.70 (787.03) |
| heart | 9028.75 (427.18) | 6286.26b (862.72) | 6149.73b (61.00) | 11,625.11b (959.87) | 8490.81 (362.74) |
| bone | 9147.74 (535.58) | 6240.46b (928.96) | 9803.12 (1286.41) | 10,352.02 (768.61) | 9617.37 (609.13) |
a
AUC, area under the curve. AUC0-INF, area under the curve extrapolated to infinity.
b
P < 0.05 for comparison with pac-T.