Table 3.
Calculated Cmaxs for All Five Formulations of Paclitaxel in All Analyzed Tissuesa
|
Cmax, (SD), ng/mL |
|||||
|---|---|---|---|---|---|
| solvent-based paclitaxel (pac-T) |
nab-Paclitaxel (nab-P) | mouse albumin nab-paclitaxel (m-nab-P) |
micellar paclitaxel (pac-P) |
polymeric nanoparticle paclitaxel (pac-G) |
|
| plasma | 17,766.67 (1504.44) | 2876.67b (531.26) | 2753.33b (494.00) | 3895.00b (736.19) | 5073.33b (754.08) |
| blood | 8766.67 (1056.33) | 2093.33b (328.68) | 1390.00b (175.78) | 2485.00b (552.97) | 2653.33b (325.32) |
| liver | 39,083.33 (2961.56) | 48,083.33b (3394.24) | 45,000.00 (6415.61) | 58,000.00b (3905.12) | 67,166.67b (5387.10) |
| stomach | 5250.00 (200.00) | 5445.00 (755.20) | 6016.67b (388.37) | 8283.33b (361.71) | 8350.00b (676.39) |
| muscle | 2163.33 (87.80) | 2246.67 (361.47) | 2230.00 (252.93) | 2741.67b (280.73) | 2493.33 (407.87) |
| skin | 1626.67 (286.37) | 1430.00 (178.96) | 1348.33 (168.55) | 2345.00b (296.35) | 1681.67 (254.08) |
| fat | 1040.00 (383.63) | 745.00 (161.17) | 1260.00 (212.31) | 1961.67b (228.82) | 1446.67 (223.68) |
| spleen | 8400.00 (936.75) | 5383.33b (321.46) | 5466.67b (550.76) | 6050.00b (278.39) | 6466.67b (431.08) |
| lung | 10,700.00 (1300.00) | 6583.33b (378.60) | 6350.00b (132.29) | 11,300.00 (926.01) | 9250.00 (2402.08) |
| brain | 145.83 (19.76) | 56.68b (10.09) | 87.00b (10.64) | 95.83b (14.29) | 94.17b (21.26) |
| uterus | 3358.33 (197.63) | 2915.00b (160.39) | 2261.67b (568.71) | 3020.00 (500.22) | 2271.67b (563.68) |
| intestine | 15,550.00 (1758.55) | 13,533.33 (1382.33) | 8733.33b (652.56) | 13,900.00 (1517.40) | 13,266.67 (2617.41) |
| pancreas | 11,300.00 (1361.07) | 10,116.67 (837.16) | 10,083.33 (301.39) | 8583.33b (956.99) | 10,033.33 (208.17) |
| kidney | 20,166.67 (1286.79) | 14,800.00b (2146.51) | ll,166.67b (682.52) | 20,300.00 (1116.92) | 23,583.33 (5460.16) |
| fat pad | 1595.00 (126.19) | 1543.33 (240.02) | 1825.00 (180.07) | 2128.33b (120.03) | 1826.67 (197.57) |
| heart | 7533.33 (534.63) | 5650.00b (264.58) | 6000.00b (433.01) | 10,700.00b (950.00) | 9150.00 (1650.00) |
| bone | 2163.33 (62.52) | 1940.00 (149.33) | 2310.00 (188.22) | 3166.67b (378.99) | 2871.67b (304.40) |
a
Cmax, maximum concentration.
b
P < 0.05 for comparison with pac-T.