Table 2.
Univariate and multivariate Cox analysis of overall survival in breast PD patients.
| Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age, years | ||||
| <59 | ||||
| 59–70 | 2.422 (1.119–5.244) | 0.025 | ||
| >70 | 4.354 (2.250–8.427) | 0.001 | ||
| Tumor size, mm | ||||
| 28.0 | ||||
| 28.0–57.0 | 2.301 (1.144–4.629) | 0.019 | ||
| ≥57.0 | 6.431 (3.351–12.275) | 2.018 | ||
| Race | ||||
| White | ||||
| Black | 0.831 (0.372–1.856) | 0.652 | ||
| Other | 0.464 (0.120–1.797) | 0.266 | ||
| Grade | ||||
| I–II | ||||
| III–IV | 2.576 (1.288–5.153) | 0.007 | 2.697 (1.286–5.654) | 0.009 |
| Histological type | ||||
| PD | ||||
| PD-IDC | 0.239 (0.074–0.772) | 0.017 | 0.197 (0.054–0.726) | 0.015 |
| PD-DCIS | 0.383 (0.077–1.906) | 0.241 | 0.213 (0.036–1.251) | 0.087 |
| AJCC | ||||
| I | ||||
| II | 1.529 (0.574–4.074) | 0.396 | 1.124 (0.41–3.081) | 0.821 |
| III | 3.950 (1.749–8.920) | 0.001 | 7.308 (3.045–17.539) | 0.001 |
| IV | 19.774 (8.020–48.756) | 9.083 | 25.371 (9.56–67.33) | 0.001 |
| T stage | ||||
| T1 | ||||
| T2 | 1.962 (0.881–4.367) | 0.099 | ||
| T3 | 3.442 (1.291–9.173) | 0.013 | ||
| T4 | 7.188 (3.504–14.745) | 7.420 | ||
| N stage | ||||
| N0 | ||||
| N1 | 3.351 (1.615–6.951) | 0.001 | ||
| N2 | 4.041 (1.715–9.521) | 0.001 | ||
| N3 | 5.767 (2.318–14.352) | 0.001 | ||
| M stage | ||||
| M0 | ||||
| M1 | 9.863 (5.090–19.112) | 1.196 | ||
| Surgery | ||||
| No | ||||
| Yes | 0.235 (0.073–0.760) | 0.016 | 0.265 (0.071–0.994) | 0.049 |
| Radiotherapy | ||||
| No | ||||
| Yes | 0.787 (0.434–1.427) | 0.430 | ||
| Chemotherapy | ||||
| No | ||||
| Yes | 0.603 (0.346–1.050) | 0.074 | 0.279 (0.15–0.52) | <0.001 |
| Breast subtype | ||||
| HR–/HER2– | ||||
| HR–/HER2+ | 1.241 (0.359–4.286) | 0.733 | ||
| HR+/HER2– | 1.331 (0.388–4.570) | 0.649 | ||
| HR+/HER2+ | 1.726 (0.503–5.926) | 0.385 | ||
| ER | ||||
| Negative | ||||
| Positive | 1.314 (0.738–2.342) | 0.354 | ||
| PR | ||||
| Negative | ||||
| Positive | 0.670 (0.373–1.204) | 0.181 | ||
| HER2 | ||||
| Negative | ||||
| Positive | 1.148 (0.648–2.032) | 0.637 | ||
| Marital status | ||||
| No | ||||
| Yes | 0.388 (0.214–0.704) | 0.002 | 0.354 (0.186–0.674) | 0.002 |
PD: Paget disease; PD-IDC: PD with invasive ductal carcinoma; PD-DCIS: PD with ductal carcinoma in situ; HR: hazard ratio; CI: confidence interval; AJCC: American Joint Committee on Cancer; ER: estrogen receptor; PR: progesterone receptor; HER2: human epidermal growth factor 2-neu.