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. 2022 Feb 7;119(7):e2112696119. doi: 10.1073/pnas.2112696119

Fig. 5.

Fig. 5.

Introduction of KDM6A via mucoadhesive mRNA NPs in mice bearing orthotopic BCa tumors could inhibit metastasis potential of BCa. (A) Representative images of the entire bladders bearing orthotopic primary BCa tumors in different groups. (B) The weight (mg) and the size changes (% compared with the PBS group) of the harvested bladders from different groups. Data shown as means ± SEM (n = 10) with a two-tailed Student’s t test (**P < 0.01, ****P < 0.0001). (C) Representative H&E staining sections from the entire bladders bearing orthotopic primary BCa tumors in different groups (Scale bars in raw images, 1.25 mm; Scale bars in enlarged images, 100 µm). (D) Representative images of the maximum-volume lymph nodes collected from each group (n = 10). (E) Histogram analysis of the volume calculated from all the lymph nodes in different groups. Data shown as means ± SEM (n = 10) with a two-tailed Student’s t test (***P < 0.001). (F) Representative H&E staining images of the lymph nodes from different groups (Scale bars, 400 μm).