TABLE 2.

DOAC levels according to increasing maintenance doses of the anticonvulsant drug

Drug type	Dose (mg)	DOAC type	DOAC dose (mg) a	Timing	DOAC level (ng/ml)	Classification
Carbamazepine	200	Dabigatran	75	Trough	24	Low
Carbamazepine	200	Apixaban	5	Peak	179	Normal
Carbamazepine	300	Apixaban	5	Peak	466	High
Carbamazepine	400	Apixaban	5	Peak	67	Low
Carbamazepine	400	Apixaban	5	Peak	108	Normal
Carbamazepine	400	Rivaroxaban	20 once a day	Peak	161	Low
Carbamazepine	400	Rivaroxaban	20 once a day	Peak	236	Normal
Carbamazepine	400	Apixaban	2.5	Trough	Undetectable	Low
Carbamazepine	400	Apixaban	5	Peak	51	Low
Carbamazepine	800	Apixaban	5	Peak	102	Normal
Carbamazepine	1000	Apixaban	5	Peak	223	Normal
Phenytoin	200	Rivaroxaban	20 once a day	Trough	39	Normal
Phenytoin	200	Edoxaban	30 once a day	Trough	20	Normal
Phenytoin	200	Dabigatran	110	Trough	Undetectable	Low
Phenytoin	300	Apixaban	5	Peak	23	Low
Phenytoin	400	Apixaban	5	Trough	32	Low
Phenytoin	400	Apixaban	5	Peak	32	Low
Phenytoin	400	Rivaroxaban	15	Trough	77	Normal
Phenytoin	750	Apixaban	5	Peak	171	Normal

Abbreviation: DOAC, direct oral anticoagulant.

^a Doses are twice a day unless otherwise specified.