TABLE 3.

Thromboembolic and bleeding events according to anticoagulant treatment and antiseizure drugs

Sex a	Age, y	OAC a	Indication a	DOAC level classification/median TTR (%) a	Antiepileptic drug	Dose (mg)	Indication	Outcome
F	71	Apixaban 5 mg BID	AF	‐	Carbamazepine	600	Epilepsy	Stroke
M	71	Rivaroxaban 20 mg	VTE	‐	Phenytoin	300	Epilepsy	Deep vein thrombosis
F	63	Rivaroxaban 15 mg BID	VTE	Normal	Phenytoin	400	Epilepsy	Deep vein thrombosis
F	89	Apixaban 5 mg BID	AF	Normal	Phenytoin	750	Epilepsy	Intracranial hemorrhage
F	89	Warfarin	AF	56	Carbamazepine	200	Pain management	Fatal stroke
M	61	Warfarin	MHV	49	Phenytoin	200	Epilepsy	Aortic mechanical valve thrombosis
F	73	Warfarin	AF	59	Phenytoin	300	Epilepsy	Acute myocardial infarction
M	77	Warfarin	VTE	78	Phenytoin	400	Epilepsy	Stroke
M	76	Warfarin	AF	90	Phenytoin	400	Epilepsy	Stroke
M	69	Warfarin	AF	94	Phenytoin	400	Epilepsy	Acute myocardial infarction
M	84	Warfarin	AF	75	Carbamazepine	400	Epilepsy	Fatal subdural hematoma
M	58	Warfarin	AF	67	Carbamazepine	400	Epilepsy	Rectal bleeding
F	72	Warfarin	AF	70	Phenytoin	200	Epilepsy	Intracranial hemorrhage

Abbreviations: AF, atrial fibrillation; BID, twice per day; DOAC, direct oral anticoagulant; F, female; M, male; MHV, mechanical heart valve; OAC, oral anticoagulant; TTR, time in therapeutic range; VTE, venous thromboembolism.

^a The median TTR corresponds to the median of all the annual TTRs available for each patient.