Table 2.
CDC MIS-C case definition
| Criteria | Specifications |
|---|---|
| Age | < 21 years |
| AND | |
| Fever | > 38.0 °C for ≥ 24 h or report of subjective fever ≥ 24 h |
| AND | |
| Laboratory evidence of inflammation | ≥ 1 of the following: CRP, ESR, fibrinogen, procalcitonin, d-dimer, ferritin, lactic acid dehydrogenase, IL-6, elevated neutrophils, reduced lymphocytes, low albumin |
| AND | |
| Evidence of clinically significant illness requiring hospitalization with multisystem organ involvement | > 2 organ involvement (cardiac, kidney, respiratory, hematologic, gastrointestinal, dermatologic, neurological) |
| AND | |
| Evidence of recent or current SARS-CoV-2 infection | Positive RT-PCR, serology, antigen test, or COVID-19 exposure within the 4 weeks prior to the onset of symptoms |
| AND | |
| No alternative plauusible diagnoses |