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. 2022 Feb 3;12:792644. doi: 10.3389/fendo.2021.792644

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Copyright © 2022 Ocampo Daza, Bergqvist and Larhammar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Duplication scheme of OTR/VTR genes through the 1R/2R and 3R whole-genome duplications. Gene losses following WGDs are indicated by ⦸ symbols. D0-D3 designations refer to paralogous chromosome blocks in jawed vertebrate genomes that originated in 1R/2R, as per (9).