Table 2:

Significantly activated and deactivated (z-scores positive and negative, respectively) regions associated with the best-fit model from the guided PCA analysis.

Region	BA	x	y	z	z-max
Whole brain
Insula	13	−44	−20	16	5.61
Middle temporal gyrus	21	64	−54	2	3.28
Cingulate gyrus	24	4	10	28	3.02
Cingulate gyrus	24	0	−10	42	2.79
Inferior parietal lobule	40	52	−50	42	2.68
Middle temporal gyrus	21	−60	−56	8	2.79
Cuneus	18	4	−72	22	2.24
Insula	13	52	−32	20	2.11
Middle frontal gyrus	10	32	58	2	−7.13
Postcentral gyrus	40	−46	−32	52	−3.36
Middle temporal gyrus	21	−54	−28	−8	−2.98
Claustrum	*	−28	16	−2	−2.32
Cuneus	18	−4	−88	18	−2.23
Inferior frontal gyrus	47	36	20	−6	−2.06
Inferior frontal gyrus	9	−48	8	28	−2.03
Middle occipital gyrus	19	34	−84	12	−2.02
In DTI ROI
Medial frontal gyrus	25	10	16	−16	2.41
Medial frontal gyrus	25	10	18	−18	1.66
In BA25 explicit Talairach mask
Anterior cingulate	25	4	4	−4	2.55
Medial frontal gyrus	25	10	10	−18	2.46
Anterior cingulate	25	2	6	−4	2.15
Medial frontal gyrus	25	12	14	−18	2.06
Anterior cingulate	25	2	2	−4	1.99
Subcallosal gyrus	25	6	12	−14	1.98
Anterior cingulate	25	−2	12	−4	1.92
Anterior cingulate	25	−2	2	−4	1.82

Note: z-scores are estimates based on the bootstrapping procedure described in the Methods. Local maxima determined by FSL during cluster analysis (t > 2.45, cluster threshold p < 0.1) evaluated with the Talairach Daemon Client (http://www.talairach.org/client.html) to determine their nearest Broadman Area within the range indicated in the “Range (mm)” column.