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. 2022 Feb 16;23:7. doi: 10.1186/s12865-022-00480-w

Fig. 5.

Fig. 5

Experimental validation of IgM-mediated neutralization. A. Median fluorescent intensity (MFI) levels of RBD-specific IgG, IgA, IgM observed pre- (filled circles) and post- (hollow squares) IgM depletion. Mean fold change in MFI across samples for each isotype is indicated below the figure. B. Neutralization titers pre- and post-IgM depletion. C. Comparison of RBD-specific Ig levels to neutralization titer. Statistical significance (two-tailed p value) of Spearman correlation coefficients reported in inset